Interfering with Calcium Homeostasis

Title: The Marine-Derived Polyketide Endoperoxide 1 Plakortide F Acid Mediates its Antifungal Activity by 2 Interfering with Calcium Homeostasis 3 4 5 Authors: Tao Xu, Qin Feng, Melissa R. Jacob, Bharathi Avula, Melanie M. Mask, 6 Scott R. Baerson, Siddharth K. Tripathi, Rabab Mohammed, Mark T. 7 Hamann, Ikhlas A. Khan, Larry A. Walker, Alice M. Clark, and 8 Ameeta K. Agarwal 9 10 11 Institutions: National Center for Natural Products Research, Department of 12 Pharmacognosy, Department of Pharmacology, Department of Chemistry & 13 Biochemistry, University of Mississippi, University, MS 38677; and United 14 States Department of Agriculture, Agricultural Research Service, Natural 15 Products Utilization Research Unit, P.O. Box 8048, University, MS 38677. 16 17 Present address: Life Sciences Institute, 210 Washtenaw Avenue, University 18 of Michigan, Ann Arbor, MI 48109. 19 20 Present address: Pharmacognosy Department, Beni-Suef University, Salah 21 Salem Street, 62511 Beni-Suef, Egypt. 22 23 24 *Corresponding 25 Author: Ameeta K. Agarwal, National Center for Natural Products Research, School 26 of Pharmacy, University of Mississippi, University, MS 38677. Phone: (662) 27 915-1218. Fax: (662) 915-7062. E-mail: [email protected]. 28 29 30 Running Title: Antifungal Mechanism of Plakortide F Acid 31